FSU will be looking to move on from its first three losses in school history and open a season sweep of Clemson.
The Seminoles were blown out by the Tigers in their last meeting at Tallahassee, 50-14, last season.
The Panthers won the game, but were beaten for the fourth time this season by FSU.
Clemson’s offense will have a tough time shutting down FSU, with quarterback Deshaun Watson throwing for 308 yards and three touchdowns.
The Clemson offense will need to be better against the Seminoles, who ranked 31st in the country in rushing defense.
Clemson is favored by 2.7 points.
The Tigers will have to find a way to stop FSU running back Dalvin Cook, who rushed for 1,922 yards and 19 touchdowns this season.
He also had two touchdowns.
FSU quarterback Jalen Hurts had just three rushing touchdowns this year.
He had a career-high 19 last week at Florida State.
The offense will be tested by the Clemson defense, which ranked 27th nationally in scoring defense.
The defense will have its hands full against a FSU offense that was ranked 28th in the nation in scoring (22.5 points per game).
Clemson was held to 31 points in last year’s matchup.
FCS rival Georgia State was held without a touchdown against the Tigers last season, and the Bulldogs scored the last 13 points of the contest.
Clemson will need some luck in this game, as the Panthers will need more than a quick start.
This will be Clemson’s first home game since a 27-10 loss to the Bulldogs in 2017.
FBS schedule: Georgia State vs. F/+ Florida State @ Georgia Tech @ South Alabama vs. West Virginia @ Florida State (ESPN) Clemson vs. South Carolina @ South Carolina (ESPN2) Florida State vs of South Carolina State @ South Florida (ESPN3) Clemson @ Florida (ABC) Georgia Tech vs. Clemson (ESPNU) Clemson at Florida (LSN) Clemson WVU @ Clemson (ABC Sports) Georgia State @ Florida @ Florida Atlantic (ESPN U) Clemson State vs South Florida State Georgia Tech at Georgia Tech (ESPN/ESPNU/ESPN2/ESPN3/ABC)